Open AccessThe use of plasma rich in growth factors on wound healing in the skin: experimental study in rabbits
Author(s) -
MolinaMiñano Francesco,
LópezJornet Péa,
CamachoAlonso Fabio,
VicenteOrtega Vicente
Publication year - 2009
Publication title -
international wound journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.867
H-Index - 63
eISSN - 1742-481X
pISSN - 1742-4801
DOI - 10.1111/j.1742-481x.2009.00592.x
Subject(s) - medicine , inflammation , wound healing , skin repair , surgery , immunology
The objective of this study was to use autologous plasma rich in growth factors (PRGF) on wound healing in the skin in New Zealand albino rabbits and to study reepithelialisation and inflammation at 7 and 28 days. A prospective study carried out on 20 adult rabbits. Two wounds were made on the in the skin on the back of each animal; one control, and the other in which PRGF was applied. The PRGF preparation was obtained from 10 ml of whole blood. The reepithelialisation and inflammation of wounds were measured at 7 and 28 days. Reepithelialisation improved in skin at 7 days ( P = 0·007), with resolution of the inflammatory process ( P = 0·005), having significant differences with respect to the control. Therefore, PRGF accelerates reepithelialisation and reduces inflammation at 7 days in skin.