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Homeodomain‐containing protein HOXB 9 regulates expression of growth and angiogenic factors, facilitates tumor growth in vitro and is overexpressed in breast cancer tissue
Author(s) -
Shrestha Bishakha,
Ansari Khairul I.,
Bhan Arunoday,
Kasiri Sahba,
Hussain Imran,
Mandal Subhrangsu S.
Publication year - 2012
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2012.08733.x
Subject(s) - homeobox , carcinogenesis , biology , cancer research , cell growth , angiogenesis , microbiology and biotechnology , transcription factor , cancer , gene , genetics
HOXB 9 is a homeobox‐containing gene and is critical for the development of mammary gland and sternum. HOXB 9 is also regulated by estrogen and is critical for angiogenesis. We investigated the biochemical roles of HOXB 9 and its homeodomain in cell‐cycle progression and tumorigenesis. Our studies demonstrated that HOXB 9 is overexpressed in breast cancer tissue. HOXB 9 overexpression stimulated 3 D formation in soft agar assay. HOXB 9 binds to the promoters of various tumor growth and angiogenic factors and regulates their expression. The homeodomain of HOXB 9 plays crucial roles in transcriptional regulation of tumor growth factors and also in 3 D colony formation, indicating crucial roles of the HOXB 9 homeodomain in tumorigenesis. Overall, we demonstrated that HOXB 9 is a critical regulator of tumor growth factors and is associated with tumorigenesis.