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Type 2C protein phosphatases in plants
Author(s) -
Fuchs Stefan,
Grill Erwin,
Meskiene Irute,
Schweighofer Alois
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2012.08670.x
Subject(s) - abscisic acid , phosphatase , protein kinase a , receptor , function (biology) , kinase , biology , enzyme , biochemistry , signal transduction , microbiology and biotechnology , gene
Type 2C protein phosphatases (PP2Cs) form a structurally unique class of Mg 2+ ‐/Mn 2+ ‐dependent enzymes. PP2Cs are evolutionary conserved from prokaryotes to higher eukaryotes and play a prominent role in stress signalling. In this review, we focus on the evolution, function and regulation of the plant PP2Cs. Members of a subclass of plant PP2Cs counteract mitogen‐activated protein kinase pathways, whereas members of other subfamilies function as co‐receptors for the phytohormone abscisic acid. Recent structural analyses of abscisic acid receptors have elucidated the mode of ligand‐dependent regulation and substrate targeting.