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Amino acid sensing mechanisms: an Achilles heel in cancer?
Author(s) -
Lamb Richard F.
Publication year - 2012
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2012.08659.x
Subject(s) - amino acid , nutrient , extracellular , cancer cell , heel , microbiology and biotechnology , chemistry , biochemistry , biology , cancer , ecology , genetics , anatomy
The act of increasing mass, either in non‐dividing cells or in dividing cells seeking to provide new material for daughter cells, depends upon the continued presence of extracellular nutrients in order to conserve mass. For amino acid nutrients, it appears that their insufficiency for new protein synthesis is actively monitored by both prokaryotic and eukaryotic cells, eliciting appropriate cellular responses that may depend not only on bulk nutrient supply, but also on the abundance of specific amino acids.