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The signaling mechanism of ambient pH sensing and adaptation in yeast and fungi
Author(s) -
Maeda Tatsuya
Publication year - 2012
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2012.08548.x
Subject(s) - escrt , endosome , microbiology and biotechnology , saccharomyces cerevisiae , signal transduction , transcription factor , biology , yeast , vacuolar protein sorting , chemistry , biochemistry , gene , intracellular
The four protein complexes termed endosomal sorting complexes required for transport (ESCRT) are key mediators of multivesicular body sorting/formation, retroviral budding and cell abscission, which share a membrane deformation process with the same topological change: vesicles budding away from the cytoplasm. Independent studies of the signal transduction pathways that mediate ambient pH sensing and adaptation in yeast and fungi revealed that these pathways share a conserved signaling mechanism that utilizes ESCRT complexes for its activation. This pathway in Saccharomyces cerevisiae , termed the Rim101 pathway, consists of both a sensing complex, which senses ambient alkaline pH, and a proteolytic complex, which proteolyzes and thereby activates the key transcription factor Rim101. Since the proteolytic complex is thought to be formed and activated on a platform of a multimerized ESCRT‐III component Snf7, the organization, regulation and function of this pathway are dependent on the function of ESCRT complexes.