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The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders
Author(s) -
Kandanearatchi Apsara,
Brew Bruce J.
Publication year - 2012
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2012.08500.x
Subject(s) - kynurenine pathway , neurocognitive , quinolinic acid , kynurenine , human immunodeficiency virus (hiv) , neuroscience , psychology , medicine , cognition , psychiatry , immunology , biology , genetics , tryptophan , amino acid
This brief review will first consider HIV associated neurocognitive disorder followed by the current understanding of its neuropathogenesis. Against this background the role of the kynurenine pathway will be detailed. Evidence both direct and indirect will be discussed for involvement of the kynurenine pathway at each step in the neuropathogenesis of HIV associated neurocognitive disorder.