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Cellular biochemistry of the multifunctional transglutaminase 2: challenging issues and novel concepts
Author(s) -
Fésüs László
Publication year - 2011
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2011.08403.x
Subject(s) - tissue transglutaminase , biochemistry , chemistry , computational biology , biology , microbiology and biotechnology , enzyme
The transglutaminase TG2 can do a lot more than just transamidation: it has multiple biochemical activities, appears in various cell compartments, and has been implicated in a broad range of cellular processes and pathologies. Decades after its discovery, this enigmatic protein still intrigues researchers. Some of the most recent and compelling findings concerning TG2 are reviewed in four minireviews in this issue of FEBS Journal .