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Membrane protein integration into the endoplasmic reticulum
Author(s) -
MartínezGil Luis,
Saurí Ana,
MartiRenom Marc A.,
Mingarro Ismael
Publication year - 2011
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2011.08185.x
Subject(s) - endoplasmic reticulum , sec61 , stim1 , membrane protein , integral membrane protein , microbiology and biotechnology , translocon , membrane contact site , ribosome , biogenesis , biology , membrane , chemistry , biochemistry , gene , rna
Most integral membrane proteins are targeted, inserted and assembled in the endoplasmic reticulum membrane. The sequential and potentially overlapping events necessary for membrane protein integration take place at sites termed translocons, which comprise a specific set of membrane proteins acting in concert with ribosomes and, probably, molecular chaperones to ensure the success of the whole process. In this minireview, we summarize our current understanding of helical membrane protein integration at the endoplasmic reticulum, and highlight specific characteristics that affect the biogenesis of multispanning membrane proteins.