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Bacterial inclusion bodies as active and dynamic protein ensembles
Author(s) -
Lotti Marina
Publication year - 2011
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2011.08162.x
Subject(s) - inclusion bodies , aggregate (composite) , protein aggregation , computational biology , inclusion (mineral) , recombinant dna , bacterial protein , biology , chemistry , bacteria , nanotechnology , biochemistry , materials science , genetics , mineralogy , gene
A number of recombinant proteins aggregate in bacterial host cells building insoluble inclusion bodies. We summarise recent insight in the functional and structural properties of inclusion bodies, their dynamics, and their biological role. Potential uses of aggregated proteins in biotechnology and as models to study amyloids formation are described, as well as the computational methods available to predict aggregation propensity.