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Chromatin structure at active genes
Author(s) -
Staynov Dontcho,
CraneRobinson Colyn
Publication year - 2011
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2011.08152.x
Subject(s) - chromatin , nucleosome , heterochromatin , enhancer , biology , histone , gene , chia pet , microbiology and biotechnology , genetics , gene expression
For gene switching, chromatin must be manipulated, a process initiating at key cis ‐controlling elements, labelled operationally as DNaseI hypersensitive sites (DHS). This minireview series expands on how the remodelling of chromatin structure comes about and the consequences for gene activation and repression