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Natriuretic peptide metabolism, clearance and degradation
Author(s) -
Potter Lincoln R.
Publication year - 2011
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2011.08082.x
Subject(s) - npr2 , npr1 , neprilysin , natriuretic peptide , receptor , atrial natriuretic peptide , insulin degrading enzyme , intracellular , peptide , endopeptidase , medicine , biology , endocrinology , biochemistry , chemistry , enzyme , heart failure
Atrial natriuretic peptide, B‐type natriuretic peptide and C‐type natriuretic peptide constitute a family of three structurally related, but genetically distinct, signaling molecules that regulate the cardiovascular, skeletal, nervous, reproductive and other systems by activating transmembrane guanylyl cyclases and elevating intracellular cGMP concentrations. This review broadly discusses the general characteristics of natriuretic peptides and their cognate signaling receptors, and then specifically discusses the tissue‐specific metabolism of natriuretic peptides and their degradation by neprilysin, insulin‐degrading enzyme, and natriuretic peptide receptor‐C.