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RIP1 comes back to life as a cell death regulator in TNFR1 signaling
Author(s) -
O’Donnell Marie Anne,
Ting Adrian T.
Publication year - 2011
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2011.08016.x
Subject(s) - programmed cell death , microbiology and biotechnology , apoptosis , biology , tumor necrosis factor alpha , signal transduction , necroptosis , regulator , necrosis , tumor necrosis factor receptor 1 , receptor , cancer research , tumor necrosis factor receptor , immunology , genetics , gene
Cell death induction by tumor necrosis factor has been an intensively studied area for the last two decades. Although it may appear that the skeleton should have been picked clean by now, new secrets about tumor necrosis factor death signaling are still being uncovered. In particular, the recent evidence that ubiquitination of the death kinase receptor‐interacting protein 1 regulates its participation in apoptotic and necrotic cell death is opening up unexplored avenues in the catacombs of tumor necrosis factor death signaling. In this minireview, we focus on two major cell‐death checkpoints that determine whether receptor‐interacting protein 1 functions as a pro‐survival or pro‐death molecule.