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Organizing signal transduction through A‐kinase anchoring proteins (AKAPs)
Author(s) -
Logue Jeremy S.,
Scott John D.
Publication year - 2010
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2010.07866.x
Subject(s) - signal transduction , signaling proteins , protein kinase a , microbiology and biotechnology , scaffold protein , signal transducing adaptor protein , biology , effector , second messenger system , kinase
A fundamental role for protein–protein interactions in the organization of signal transduction pathways is evident. Anchoring, scaffolding and adapter proteins function to enhance the precision and directionality of these signaling events by bringing enzymes together. The cAMP signaling pathway is organized by A‐kinase anchoring proteins. This family of proteins assembles enzyme complexes containing the cAMP‐dependent protein kinase, phosphoprotein phosphatases, phosphodiesterases and other signaling effectors to optimize cellular responses to cAMP and other second messengers. Selected A‐kinase anchoring protein signaling complexes are highlighted in this minireview.