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Docking proteins
Author(s) -
Brummer Tilman,
SchmitzPeiffer Carsten,
Daly Roger J.
Publication year - 2010
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2010.07865.x
Subject(s) - receptor tyrosine kinase , microbiology and biotechnology , receptor protein tyrosine kinases , protein tyrosine phosphatase , fibroblast growth factor receptor , tyrosine kinase , receptor , ror1 , biochemistry , proto oncogene tyrosine protein kinase src , insulin like growth factor 1 receptor , chemistry , biology , kinase , platelet derived growth factor receptor , signal transduction , fibroblast growth factor , growth factor
Docking proteins comprise a distinct category of intracellular, noncatalytic signalling protein, that function downstream of a variety of receptor and receptor‐associated tyrosine kinases and regulate diverse physiological and pathological processes. The growth factor receptor bound 2‐associated binder/Daughter of Sevenless, insulin receptor substrate, fibroblast growth factor receptor substrate 2 and downstream of tyrosine kinases protein families fall into this category. This minireview focuses on the structure, function and regulation of these proteins.