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Small‐molecule modulators of zymogen activation in the fibrinolytic and coagulation systems
Author(s) -
Hasumi Keiji,
Yamamichi Shingo,
Harada Tomotaka
Publication year - 2010
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2010.07783.x
Subject(s) - zymogen , coagulation , mechanism (biology) , chemistry , tissue factor , small molecule , coagulation system , microbiology and biotechnology , biochemistry , biology , medicine , enzyme , philosophy , epistemology
The coagulation and fibrinolytic systems are central to the hemostatic mechanism, which works promptly on vascular injury and tissue damage. The rapid response is generated by specific molecular interactions between components in these systems. Thus, the regulation mechanism of the systems is programmed in each component, as exemplified by the elegant processes in zymogen activation. This review describes recently identified small molecules that modulate the activation of zymogens in the fibrinolytic and coagulation systems.