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Making sense of G‐quadruplex and i‐motif functions in oncogene promoters
Author(s) -
Brooks Tracy A.,
Kendrick Samantha,
Hurley Laurence
Publication year - 2010
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2010.07759.x
Subject(s) - promoter , g quadruplex , motif (music) , biology , telomerase , telomere , structural motif , circumstantial evidence , computational biology , genetics , dna , microbiology and biotechnology , biochemistry , gene , philosophy , gene expression , political science , law , aesthetics
The presence and biological importance of DNA secondary structures in eukaryotic promoters are becoming increasingly recognized among chemists and biologists as bioinformatics in vitro and in vivo evidence for these structures in the c‐Myc, c‐Kit, KRAS, PDGF‐A, hTERT, Rb, RET and Hif‐1α promoters accumulates. Nevertheless, the evidence remains largely circumstantial. This minireview differs from previous ones in that here we examine the diversity of G‐quadruplex and i‐motif structures in promoter elements and attempt to categorize the different types of arrangements in which they are found. For the c‐Myc G‐quadruplex and Bcl‐2 i‐motif, we summarize recent biological and structural studies.