Premium
BRCA1 16 years later: DNA damage‐induced BRCA1 shuttling
Author(s) -
Yang Eddy S.,
Xia Fen
Publication year - 2010
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2010.07734.x
Subject(s) - dna damage , dna repair , microbiology and biotechnology , dna , genome instability , suppressor , non homologous end joining , biology , cancer research , dna damage repair , chemistry , gene , genetics
The tumor suppressor, breast cancer susceptibility gene 1 (BRCA1), plays an integral role in the maintenance of genome stability and, in particular, the cellular response to DNA damage. Here, the emerging role of BRCA1 in nonhomologous end‐joining‐mediated DNA repair following DNA damage will be reviewed, as well as the activation of apoptotic pathways. The control of these functions via DNA damage‐induced BRCA1 shuttling will also be discussed, in particular BRCA1 shuttling induced by erlotinib and irradiation. Finally, the potential targeting of BRCA1 shuttling as a novel strategy to sensitize cells to DNA damage will be entertained.