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Cytoskeleton‐modulating effectors of enteropathogenic and enterohemorrhagic Escherichia coli : a case for EspB as an intrinsically less‐ordered effector
Author(s) -
Hamada Daizo,
Hamaguchi Mitsuhide,
Suzuki Kayo N.,
Sakata Ikuhiro,
Yanagihara Itaru
Publication year - 2010
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2010.07655.x
Subject(s) - effector , enteropathogenic escherichia coli , microbiology and biotechnology , escherichia coli , cytoskeleton , chemistry , biology , cell , biochemistry , gene
Enterohemorrhagic and enteropathogenic Escherichia coli produce various effector proteins that are directly injected into the host‐cell cytosol through the type III secretion system. E. coli secreted protein (Esp)B is one such effector protein, and affects host‐cell morphology by reorganizing actin networks. Unlike most globular proteins that have well‐ordered, rigid structures, the structures of type III secretion system effectors from pathogenic Gram‐negative bacteria, including EspB, are often less well‐ordered. This minireview focuses on the functional relationship between the structural properties of these proteins and their roles in type III secretion system‐associated pathogenesis.