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Alternative splicing: regulation of HIV‐1 multiplication as a target for therapeutic action
Author(s) -
Tazi Jamal,
Bakkour Nadia,
Marchand Virginie,
Ayadi Lilia,
Aboufirassi Amina,
Branlant Christiane
Publication year - 2010
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2009.07522.x
Subject(s) - rna splicing , rna , biology , computational biology , viral replication , alternative splicing , human immunodeficiency virus (hiv) , genetics , messenger rna , virology , gene , virus
The retroviral life cycle requires that significant amounts of RNA remain unspliced and perform several functions in the cytoplasm. Thus, the full‐length RNA serves both the viral genetic material that will be encapsulated in viral particles and the mRNA encoding structural and enzymatic proteins required for viral replication. Simple retroviruses produce one single‐spliced env RNA from the full‐length precursor RNA, whereas complex retroviruses, such as HIV, are characterized by the production of multiple‐spliced RNA species. In this review we will summarize the current acknowledge about the HIV‐1 alternative splicing mechanism and will describe how this malleable process can help further understanding of infection, spread and dissemination through splicing regulation. Such studies coupled with the testing of splicing inhibitors should help the development of new therapeutic antiviral agents.