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From meiosis to postmeiotic events: The secrets of histone disappearance
Author(s) -
Gaucher Jonathan,
Reynoird Nicolas,
Montellier Emilie,
Boussouar Fayçal,
Rousseaux Sophie,
Khochbin Saadi
Publication year - 2010
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2009.07504.x
Subject(s) - histone , meiosis , nucleosome , biology , genetics , genome , microbiology and biotechnology , spermatogenesis , evolutionary biology , computational biology , dna , gene , endocrinology
One of the most obscure phenomena in modern biology is the near genome‐wide displacement of histones that occurs during the postmeiotic phases of spermatogenesis in many species. Here we review the literature to show that, during spermatogenic differentiation, three major molecular mechanisms come together to ‘prepare’ the nucleosomes for facilitated disassembly and histone removal.