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Calmodulin‐mediated regulation of the epidermal growth factor receptor
Author(s) -
SánchezGonzález Pablo,
Jellali Karim,
Villalobo Antonio
Publication year - 2010
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2009.07469.x
Subject(s) - calmodulin , epidermal growth factor receptor , microbiology and biotechnology , epidermal growth factor , receptor , biology , growth factor receptor inhibitor , chemistry , biochemistry , enzyme
In this review, we first describe the mechanisms by which the epidermal growth factor receptor generates a Ca 2+ signal and, subsequently, we compile the available experimental evidence regarding the role that the Ca 2+ /calmodulin complex, formed after the rise in cytosolic free Ca 2+ concentration, exerts on the receptor. We focus not only on the indirect action that Ca 2+ /calmodulin exerts on the epidermal growth factor receptor, as a result of the activation of distinct calmodulin‐dependent kinases, but also, and more extensively, on the direct interaction of Ca 2+ /calmodulin with the receptor. We also describe several mechanistic models that could account for the Ca 2+ /calmodulin‐mediated regulation of epidermal growth factor receptor activity. The control exerted by calmodulin on distinct epidermal growth factor receptor‐mediated cellular functions is also discussed. Finally, the phosphorylation of this Ca 2+ sensor by the epidermal growth factor receptor is highlighted.