Premium
Viral entry mechanisms: the increasing diversity of paramyxovirus entry
Author(s) -
Smith Everett C.,
Popa Andreea,
Chang Andres,
Masante Cyril,
Dutch Rebecca Ellis
Publication year - 2009
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2009.07401.x
Subject(s) - viral entry , paramyxoviridae , viral envelope , lipid bilayer fusion , virology , biology , glycoprotein , measles virus , virus , human metapneumovirus , microbiology and biotechnology , viral replication , viral disease , measles , genetics , respiratory tract infections , respiratory system , vaccination , anatomy
The paramyxovirus family contains established human pathogens such as the measles virus and human respiratory syncytial virus, as well as emerging pathogens including the Hendra and Nipah viruses and the recently identified human metapneumovirus. Two major envelope glycoproteins, the attachment protein and the fusion protein, promote the processes of viral attachment and virus‐cell membrane fusion required for entry. Although common mechanisms of fusion protein proteolytic activation and the mechanism of membrane fusion promotion have been shown in recent years, considerable diversity exists in the family relating to receptor binding and the potential mechanisms of fusion triggering.