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ERK and cell death: ERK1/2 in neuronal death
Author(s) -
Subramaniam Srinivasa,
Unsicker Klaus
Publication year - 2010
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2009.07367.x
Subject(s) - mapk/erk pathway , programmed cell death , kinase , microbiology and biotechnology , extracellular , neuroscience , biology , protein kinase a , function (biology) , signal transduction , apoptosis , biochemistry
Extracellular signal‐regulated kinase (ERK) is a versatile protein kinase that regulates many cellular functions. Growing evidence suggests that ERK1/2 plays a crucial role in promoting cell death in a variety of neuronal systems, including neurodegenerative diseases. It is believed that the magnitude and the duration of ERK1/2 activity determine its cellular function. In this review, we summarize recent evidence for a role of ERK1/2 in neuronal death. Furthermore, we discuss the mechanisms involved in ERK1/2 mediating neuronal death.