Premium
Mechanisms of obesity and related pathologies: Transcriptional control of adipose tissue development
Author(s) -
Vernochet Cecile,
Peres Sidney B.,
Farmer Stephen R.
Publication year - 2009
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2009.07302.x
Subject(s) - adipose tissue , obesity , disease , biology , bioinformatics , identification (biology) , diabetes mellitus , medicine , endocrinology , botany
Obesity and its associated disorders, including diabetes and cardiovascular disease, have now reached epidemic proportions in the Western world, resulting in dramatic increases in healthcare costs. Understanding the processes and metabolic perturbations that contribute to the expansion of adipose depots accompanying obesity is central to the development of appropriate therapeutic strategies. This minireview focuses on a discussion of the recent identification of molecular mechanisms controlling the development and function of adipose tissues, as well as how these mechanisms contribute to the regulation of energy balance in mammals.