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Epidermal growth factor receptor‐regulated miR‐125a‐5p – a metastatic inhibitor of lung cancer
Author(s) -
Wang Guofu,
Mao Weimin,
Zheng Shu,
Ye Jingjia
Publication year - 2009
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2009.07238.x
Subject(s) - epidermal growth factor receptor , cancer research , carcinogenesis , microrna , biology , lung cancer , growth factor receptor , growth factor receptor inhibitor , epidermal growth factor , signal transduction , cancer , receptor , microbiology and biotechnology , medicine , gene , genetics
Both the epidermal growth factor receptor signaling pathway and microRNA (miRNA) play an important role in lung cancer development and progression. To address the potential role of miRNA in epidermal growth factor receptor signaling, we identified miR‐125a‐5p as a downstream target, using an miRNA array. We further demonstrated that miR‐125a‐5p inhibited migration and invasion of lung cancer cells. Moreover, miR‐125a‐5p regulated the expression of several downstream genes of epidermal growth factor receptor signaling. Importantly, examination of lung cancer samples revealed a significant correlation of miR‐125a‐5p repression with lung carcinogenesis. Taken together, our results provide compelling evidence that miR‐125a‐5p, an epidermal growth factor‐signaling‐regulated miRNA, may function as a metastatic suppressor.