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The miRNA‐192/194 cluster regulates the Period gene family and the circadian clock
Author(s) -
Nagel Remco,
Clijsters Linda,
Agami Reuven
Publication year - 2009
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2009.07229.x
Subject(s) - circadian rhythm , circadian clock , biology , period (music) , oscillating gene , clock , mechanism (biology) , microrna , bacterial circadian rhythms , molecular clock , genetics , gene , microbiology and biotechnology , neuroscience , philosophy , physics , phylogenetics , epistemology , acoustics
Several biological functions in mammals are regulated in a circadian fashion. The molecular mechanisms orchestrating these circadian rhythms have been unravelled. The biological clock, with its core transcriptional unit Bmal1/CLOCK, is composed of several self‐sustaining feedback loops. In this study, we describe another mechanism impinging on the core components of the circadian clock. Using a forward genetic screen, we identified the miR‐192/194 cluster as a potent inhibitor of the entire Period gene family. In accordance, the exogenous expression of miR‐192/194 leads to an altered circadian rhythm. Thus, our results have uncovered a new mechanism for the control of the circadian clock at the post‐transcriptional level.