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SREBPs: physiology and pathophysiology of the SREBP family
Author(s) -
Shimano Hitoshi
Publication year - 2009
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2008.06806.x
Subject(s) - lipotoxicity , overnutrition , sterol regulatory element binding protein , endocrinology , insulin resistance , medicine , biology , diabetes mellitus , sterol , cholesterol , obesity
Sterol regulatory element‐binding proteins (SREBPs) have been established as physiological regulators of lipid synthesis. The molecular mechanisms by which cellular sterol balance and nutritional states regulate SREBP activities are the current research focus of this field. Meanwhile, it has been shown that overnutrition or disturbed energy balance causes accumulation of tissue lipids, leading to metabolic disorders, often referred to as ‘lipotoxicity’. In this overview, I discuss the pathological aspects of SREBPs, which contribute to lipotoxicity in a wide variety of organs, including hepatic insulin resistance in hepatosteatosis, impaired insulin secretion in pancreatic β‐cells, diabetic nephropathy, cardiac arrythmiasis, and obesity.