Premium
Natural polyphenols as proteasome modulators and their role as anti‐cancer compounds
Author(s) -
Bonfili Laura,
Cecarini Valentina,
Amici Manila,
Cuccioloni Massimiliano,
Angeletti Mauro,
Keller Jeffrey N.,
Eleuteri Anna M.
Publication year - 2008
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2008.06696.x
Subject(s) - proteasome , effector , polyphenol , cytoplasm , antioxidant , microbiology and biotechnology , chemistry , cancer therapy , cell , cell cycle , biochemistry , cancer cell , cancer , biology , genetics
The purpose of this review is to discuss the effect of natural antioxidant compounds as modulators of the 20 S proteasome, a multi‐enzymatic multi‐catalytic complex present in the cytoplasm and nucleus of eukaryotic cells and involved in several cellular activities such as cell‐cycle progression, proliferation and the degradation of oxidized and damaged proteins. From this perspective, proteasome inhibition is a promising approach to anticancer therapy and such natural antioxidant effectors can be considered as potential relevant adjuvants and pharmacological models in the study of new drugs.