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Submembraneous microtubule cytoskeleton: interaction of TRPP2 with the cell cytoskeleton
Author(s) -
Chen XingZhen,
Li Qiang,
Wu Yuliang,
Liang Genqing,
Lara Carlos J.,
Cantiello Horacio F.
Publication year - 2008
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2008.06616.x
Subject(s) - cytoskeleton , microbiology and biotechnology , biology , endoplasmic reticulum , autosomal dominant polycystic kidney disease , cilium , cell , genetics , kidney
TRPP2, also called polycystin‐2, the gene product of PKD2 , is a membrane protein defective in 10–15% of cases of autosomal dominant polycystic kidney disease. Mutations in PKD2 are also associated with extrarenal disorders, such as hepatic cystogenesis and cardiovascular abnormalities. TRPP2 is a Ca‐permeable nonselective cation channel present in the endoplasmic reticulum and plasma membrane, as well as in cilia of renal epithelial and embryonic nodal cells, in which it likely forms part of a flow sensor. Recent studies have identified a number of TRPP2‐interacting proteins, of which many are cytoskeletal components. Work from our and other laboratories indicates that cytoskeletal partner proteins seem to play important, albeit highly complex, roles in the regulation of TRPP2 expression, localization and channel function. This minireview covers current knowledge about cytoskeletal interactions with TRPP2, and suggests that mutations in proteins of the TRPP2‐cytoskeleton complex may be implicated in the pathogenesis of autosomal dominant polycystic kidney disease.