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Protein transport across the endoplasmic reticulum membrane
Author(s) -
Rapoport Tom A.
Publication year - 2008
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2008.06588.x
Subject(s) - sec61 , endoplasmic reticulum , heterotrimeric g protein , membrane contact site , membrane protein , translocon , microbiology and biotechnology , stim1 , membrane , membrane transport protein , peripheral membrane protein , transport protein , protein targeting , chemistry , biology , biophysics , biochemistry , integral membrane protein , g protein , signal transduction
A decisive step in the biosynthesis of many eukaryotic proteins is their partial or complete translocation across the endoplasmic reticulum membrane. A similar process occurs in prokaryotes, except that proteins are transported across or are integrated into the plasma membrane. In both cases, translocation occurs through a protein‐conducting channel that is formed from a conserved, heterotrimeric membrane protein complex, the Sec61 or SecY complex. Structural and biochemical data suggest mechanisms that enable the channel to function with different partners, to open across the membrane and to release laterally hydrophobic segments of membrane proteins into lipid.