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Huntington’s disease: roles of huntingtin‐interacting protein 1 (HIP‐1) and its molecular partner HIPPI in the regulation of apoptosis and transcription
Author(s) -
Bhattacharyya Nitai P.,
Banerjee Manisha,
Majumder Pritha
Publication year - 2008
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2008.06563.x
Subject(s) - huntingtin , huntingtin protein , huntington's disease , biology , endocytic cycle , apoptosis , microbiology and biotechnology , gene , mutation , genetics , pathogenesis , transcription (linguistics) , disease , cell , immunology , medicine , mutant , endocytosis , linguistics , philosophy
Huntingtin protein (Htt), whose mutation causes Huntington’s disease (HD), interacts with large numbers of proteins that participate in diverse cellular pathways. This observation indicates that wild‐type Htt is involved in various cellular processes and that the mutated Htt alters these processes in HD. The roles of these interacting proteins in HD pathogenesis remain largely unknown. In the present review, we present evidence that Htt‐interacting protein 1 (HIP‐1), an endocytic protein, together with its interacting partner HIPPI, regulates apoptosis and gene expression, both processes being implicated in HD. Further studies are necessary to establish whether the HIPPI–HIP‐1 complex or other interacting partners of HIPPI regulate apoptosis and gene expression that are relevant to HD.