Premium
Protein kinase Cε: the mitochondria‐mediated signaling pathway
Author(s) -
Yonekawa Hiromichi,
Akita Yoshiko
Publication year - 2008
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2008.06558.x
Subject(s) - microbiology and biotechnology , ask1 , mitochondrion , protein kinase a , map2k7 , biology , mitogen activated protein kinase kinase , signal transduction , c raf , apoptosis , map kinase kinase kinase , kinase , cyclin dependent kinase 2 , chemistry , biochemistry
Mitochondria, which are the cellular energy plants, also act as the integration center of cellular signaling pathways. Apoptosis is a well‐known pathway in which mitochondria are involved. Protein kinase Cε has been classified as a novel type of protein kinase C and is involved in many cellular events regulating mitochondrial function. Much evidence has accumulated regarding the relationships between mitochondria‐mediated apoptosis and protein kinase Cε. Therefore, by focusing on these relationships, in particular the anti‐apoptotic effects of protein kinase Cε on mitochondrial function, we highlight the importance and significance of protein kinase Cε in cell survival and death.