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Protein kinase Cε: multiple roles in the function of, and signaling mediated by, the cytoskeleton
Author(s) -
Akita Yoshiko
Publication year - 2008
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2008.06557.x
Subject(s) - cytoskeleton , microbiology and biotechnology , microfilament , signal transduction , ask1 , biology , intermediate filament , signaling proteins , kinase , protein kinase a , protein kinase c , cell function , cell , chemistry , mitogen activated protein kinase kinase , biochemistry
Recent studies have established essential roles of protein kinase Cε in signaling pathways controlling various functions of microfilaments and intermediate filaments by modulating multiple cytoskeletal proteins. This review summarizes recent progress in our understanding of the roles of protein kinase Cε in the functions and signaling of microfilaments and intermediate filaments, with a focus mainly on cell–matrix and cell–cell interactions, migrations and contraction, in addition to its relevance in the development of several diseases, such as malignant tumors or cardiac disease.