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Parkinson’s disease: recent development in therapies for advanced disease with a focus on deep brain stimulation (DBS) and duodenal levodopa infusion
Author(s) -
Sydow Olof
Publication year - 2008
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2008.06295.x
Subject(s) - levodopa , deep brain stimulation , parkinson's disease , disease , medicine , stimulation , neuroscience , physical medicine and rehabilitation , psychology
Effective medical treatment for Parkinson’s disease has been available for almost 40 years. After several years of treatment with l ‐dihydroxyphenylalanine ( l ‐dopa, levodopa), however, fluctuations often occur. The patient may then experience random variations of the motor symptoms during the day. The medication becomes increasingly complicated. New therapeutic methods, deep brain stimulation and duodenal infusion of l ‐dopa, have proven to be very effective in stabilizing the fluctuations. A clinical update of Parkinson’s disease is presented together with a short review of these two methods.