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Protein tyrosine phosphatases: regulatory mechanisms
Author(s) -
Hertog Jeroen den,
Östman Arne,
Böhmer FrankD.
Publication year - 2008
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2008.06247.x
Subject(s) - protein tyrosine phosphatase , phosphatase , proteolysis , subcellular localization , tyrosine , biochemistry , microbiology and biotechnology , chemistry , receptor tyrosine kinase , protein subcellular localization prediction , biology , phosphorylation , cytoplasm , enzyme , gene
Protein‐tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post‐translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein‐tyrosine phosphatases.