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Non‐hydrolytic functions of acetylcholinesterase
Author(s) -
Greenfield Susan A.,
Zimmermann Martina,
Bond Cherie E.
Publication year - 2008
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2007.06235.x
Subject(s) - acetylcholinesterase , hydrolysis , chemistry , mathematics , biochemistry , enzyme
This review explores the possibility that acetylcholinesterase may play a pivotal, non‐hydrolytic role in neurodegeneration. More specifically, C‐terminal sequences of acetylcholinesterase may act as signalling molecules in key brain regions characteristically vulnerable to Alzheimer’s, Parkinson’s and motor neuron disease.