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What MAN1 does to the Smads
Author(s) -
Bengtsson Luiza
Publication year - 2007
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2007.05696.x
Subject(s) - bone morphogenetic protein , xenopus , transforming growth factor , microbiology and biotechnology , smad , signal transduction , biology , smad2 protein , genetics , gene
The inner nuclear membrane protein MAN1 has been identified as an important factor in transforming growth factor β/bone morphogenic protein (TGFβ/BMP) signaling. Loss of MAN1 results in three autosomal dominant diseases in humans; all three characterized by increased bone density. Xenopus embryos lacking MAN1 develop severe morphological defects. Both in humans and in Xenopus embryos the defects originate from deregulation of TGFβ/BMP signaling. Several independent studies have shown that MAN1 is antagonizing TGFβ/BMP signaling through binding to regulatory Smads. Here, recent progress in understanding MAN1 functions is summarized and a model for MAN1‐dependent regulation of TGFβ/BMP signaling is proposed.