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Nucleoplasmic lamins and their interaction partners, LAP2α, Rb, and BAF, in transcriptional regulation
Author(s) -
Dorner Daniela,
Gotzmann Josef,
Foisner Roland
Publication year - 2007
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2007.05695.x
Subject(s) - lamin , nuclear lamina , nucleoplasm , chromatin , microbiology and biotechnology , biology , transcription factor , regulation of gene expression , transcriptional regulation , transcription (linguistics) , genetics , nuclear protein , gene , nucleolus , nucleus , linguistics , philosophy
Lamins are major structural components of the nuclear envelope in multicellular eukaryotes. Particularly A‐type lamins are also located in the nucleoplasm, likely involving a specific binding partner, lamina‐associated polypeptide 2α (LAP2α). LAP2α–lamins A/C complexes in the nucleoplasm have been implicated in the regulation of gene expression by various means. They bind chromatin proteins and chromatin modifying enzymes, and can thus participate in epigenetic control pathways. Furthermore, binding of lamins A/C complexes to specific transcription factors and repressors may directly affect their transcriptional activity. LAP2α–lamins A/C also regulate retinoblastoma protein and influence cell cycle progression and differentiation, which could have important implications for molecular mechanisms of laminopathic diseases, linked to lamins A/C mutations.