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Diversity of human U2AF splicing factors
Author(s) -
Mollet Inês,
BarbosaMorais Nuno L.,
Andrade Jorge,
CarmoFonseca Maria
Publication year - 2006
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2006.05502.x
Subject(s) - rna splicing , snrnp , splicing factor , biology , alternative splicing , genetics , computational biology , gene isoform , gene , rna
U2 snRNP auxiliary factor (U2AF) is an essential heterodimeric splicing factor composed of two subunits, U2AF 65 and U2AF 35 . During the past few years, a number of proteins related to both U2AF 65 and U2AF 35 have been discovered. Here, we review the conserved structural features that characterize the U2AF protein families and their evolutionary emergence. We perform a comprehensive database search designed to identify U2AF protein isoforms produced by alternative splicing, and we discuss the potential implications of U2AF protein diversity for splicing regulation.