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Isoquinoline‐1,3,4‐trione and its derivatives attenuate β‐amyloid‐induced apoptosis of neuronal cells
Author(s) -
Zhang YaHui,
Zhang HuaJie,
Wu Fang,
Chen YiHua,
Ma XueQin,
Du JunQin,
Zhou ZhongLiang,
Li JingYa,
Nan FaJun,
Li Jia
Publication year - 2006
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2006.05483.x
Subject(s) - isoquinoline , apoptosis , programmed cell death , caspase , chemistry , protease , caspase 3 , microbiology and biotechnology , cell , amyloid (mycology) , biochemistry , pharmacology , biology , enzyme , stereochemistry , inorganic chemistry
Caspase‐3 is a programmed cell death protease involved in neuronal apoptosis during physiological development and under pathological conditions. It is a promising therapeutic target for treatment of neurodegenerative diseases. We reported previously that isoquinoline‐1,3,4‐trione and its derivatives inhibit caspase‐3. In this report, we validate isoquinoline‐1,3,4‐trione and its derivatives as potent, selective, irreversible, slow‐binding and pan‐caspase inhibitors. Furthermore, we show that these inhibitors attenuated apoptosis induced by β‐amyloid(25–35) in PC12 cells and primary neuronal cells.