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Nitric oxide and cell proliferation
Author(s) -
Villalobo Antonio
Publication year - 2006
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2006.05250.x
Subject(s) - microbiology and biotechnology , cell growth , nitric oxide , intracellular , cell cycle , cyclin , regulator , receptor tyrosine kinase , kinase , retinoblastoma protein , cyclin dependent kinase , signal transduction , biology , chemistry , cell , biochemistry , endocrinology , gene
Nitric oxide (NO • ) has been proposed to be a physiological modulator of cell proliferation, able to promote in most cases cell cycle arrest. In this review I explore the molecular basis of this mechanism of action. The modulatory action of NO • on the intracellular concentration of cGMP and the machinery directly involved in the control of cell cycle progression, including the expression and activity of diverse cyclins and cyclin‐dependent kinases, their physiological inhibitors, and the master transcriptional regulator retinoblastoma protein, will be discussed. The role of NO • in proliferation mediated by tyrosine kinase receptors such as the epidermal growth factor receptor and downstream signalling pathways will also be considered. Finally, the involvement of NO • in proliferative processes relevant for normal development will be outlined.