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The mitochondrial permeability transition from in vitro artifact to disease target
Author(s) -
Bernardi Paolo,
Krauskopf Alexandra,
Basso Emy,
Petronilli Valeria,
BlalchyDyson Elizabeth,
Di Lisa Fabio,
Forte Michael A.
Publication year - 2006
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2006.05213.x
Subject(s) - mitochondrial permeability transition pore , permeability (electromagnetism) , effector , biophysics , chemistry , microbiology and biotechnology , in vitro , membrane permeability , membrane , biology , programmed cell death , biochemistry , apoptosis
The mitochondrial permeability transition pore is a high conductance channel whose opening leads to an increase of mitochondrial inner membrane permeability to solutes with molecular masses up to ≈ 1500 Da. In this review we trace the rise of the permeability transition pore from the status of in vitro artifact to that of effector mechanism of cell death. We then cover recent results based on genetic inactivation of putative permeability transition pore components, and discuss their meaning for our understanding of pore structure. Finally, we discuss evidence indicating that the permeability transition pore plays a role in pathophysiology, with specific emphasis on in vivo models of disease.