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Peroxisome proliferator‐activated receptor α plays a vital role in inducing a detoxification system against plant compounds with crosstalk with other xenobiotic nuclear receptors
Author(s) -
Motojima Kiyoto,
Hirai Toshitake
Publication year - 2006
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2005.05060.x
Subject(s) - nuclear receptor , xenobiotic , peroxisome proliferator activated receptor , crosstalk , receptor , biology , peroxisome , detoxification (alternative medicine) , biochemistry , knockout mouse , microbiology and biotechnology , enzyme , transcription factor , gene , medicine , physics , alternative medicine , pathology , optics
Peroxisome proliferator‐activated receptor α (PPARα) is thought to play an important role in lipid metabolism in the liver. To clarify the extra‐hepatic and/or unknown function of PPARα, we previously performed a proteome analysis of the intestinal proteins and identified 17β‐hydroxysteroid dehydrogenase type 11 as a mostly induced protein by a PPARα ligand [Motojima, K. (2004) Eur. J. Biochem . 271, 4141–4146]. Because of its supposed wide substrate specificity, we examined the possibility that PPARα plays an important role in inducing detoxification systems for some natural foods by feeding mice with various plant seeds and grains. Feeding with sesame but not others often killed PPARα knockout mice but not wild‐type mice. A microarray analysis of the sesame‐induced mRNAs in the intestine revealed that PPARα plays a vital role in inducing various xenobiotic metabolizing enzymes in the mouse intestine and liver. A PPARα ligand alone could not induce most of these enzymes, suggesting that there is an essential crosstalk among PPARα and other xenobiotic nuclear receptors to induce a detoxification system for plant compounds.