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Dynamin‐related proteins and Pex11 proteins in peroxisome division and proliferation
Author(s) -
Thoms Sven,
Erdmann Ralf
Publication year - 2005
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2005.04939.x
Subject(s) - peroxisome , organelle , dynamin , microbiology and biotechnology , biology , peroxisome proliferator , cell division , function (biology) , biochemistry , cell , gene , endocytosis
The abundance and size of cellular organelles vary depending on the cell type and metabolic needs. Peroxisomes constitute a class of cellular organelles renowned for their ability to adapt to cellular and environmental conditions. Together with transcriptional regulators, two groups of peroxisomal proteins have a pronounced influence on peroxisome size and abundance. Pex11‐type peroxisome proliferators are involved in the proliferation of peroxisomes, defined here as an increase in size and/or number of peroxisomes. Dynamin‐related proteins have recently been suggested to be required for the scission of peroxisomal membranes. This review surveys the function of Pex11‐type peroxisome proliferators and dynamin‐related proteins in peroxisomal proliferation and division.