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Poly(ADP‐ribose)
Author(s) -
Bürkle Alexander
Publication year - 2005
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2005.04864.x
Subject(s) - poly adp ribose polymerase , microbiology and biotechnology , dna repair , polymerase , biology , telomere , genome instability , dna , function (biology) , gene , dna damage , chemistry , genetics
One of the most drastic post‐translational modification of proteins in eukaryotic cells is poly(ADP‐ribosyl)ation, catalysed by a family enzymes termed poly(ADP‐ribose) polymerases (PARPs). In the human genome, 18 different genes have been identified that all encode PARP family members. Poly(ADP‐ribose) metabolism plays a role in a wide range of biological structures and processes, including DNA repair and maintenance of genomic stability, transcriptional regulation, centromere function and mitotic spindle formation, centrosomal function, structure and function of vault particles, telomere dynamics, trafficking of endosomal vesicles, apoptosis and necrosis. In this article, the most recent advances in this rapidly growing field are summarized.