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Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP)
Author(s) -
Yamasaki Michiko,
Churchill Grant C.,
Galione Antony
Publication year - 2005
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2005.04860.x
Subject(s) - nicotinic agonist , chemistry , endoplasmic reticulum , biochemistry , calcium , calcium signaling , second messenger system , biophysics , signal transduction , biology , receptor , organic chemistry
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a recently described Ca 2+ mobilizing messenger, and probably the most potent. We briefly review its unique properties as a Ca 2+ mobilizing agent. We present arguments for its action in targeting acidic calcium stores rather than the endoplasmic reticulum. Finally, we discuss possible biosynthetic pathways for NAADP in cells and candidates for its target Ca 2+ release channel, which has eluded identification so far.