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Molecular mechanisms in successful peripheral regeneration
Author(s) -
Makwana Milan,
Raivich Gennadij
Publication year - 2005
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2005.04699.x
Subject(s) - regeneration (biology) , neurite , microbiology and biotechnology , intracellular , peripheral nerve injury , neuroscience , transcription factor , peripheral nerve , biology , anatomy , gene , genetics , in vitro
Peripheral nerve injury is normally followed by a robust regenerative response. Here we describe the early changes associated with injury from the initial rise in intracellular calcium and the subsequent activation of transcription factors and cytokines leading to an inflammatory reaction, and the expression of growth factors, cytokines, neuropeptides, and other secreted molecules involved in cell‐to‐cell communication promoting regeneration and neurite outgrowth. The aim of this review is to summarize the molecular mechanisms that play a part in executing successful regeneration.