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SLC39A14, a LZT protein, is induced in adipogenesis and transports zinc
Author(s) -
Tominaga Kei,
Kagata Takeshi,
Johmura Yoshikazu,
Hishida Tomoaki,
Nishizuka Makoto,
Imagawa Masayoshi
Publication year - 2005
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2005.04580.x
Subject(s) - adipogenesis , transporter , zinc finger , adipocyte , biology , microbiology and biotechnology , gene , gene expression , 3t3 l1 , genetics , biochemistry , adipose tissue , transcription factor
During adipocyte differentiation, there is an underlying complex series of gene expressions. We have previously isolated many genes whose expression levels are quickly elevated by the addition of inducers to mouse 3T3‐L1 preadipocyte cells. Here we report the isolation and characterization of SLC39A14, a member of the LZT proteins, one of the subfamilies of ZIP transporters. The expression of the SLC39A14 gene was strongly and rapidly induced at the early stages of differentiation. Moreover, it was highly restricted to the potential differentiation state of 3T3‐L1 cells and the expression level was quite low in the nonadipogenic NIH‐3T3 cells, indicating a dominant expression in adipocyte differentiation. The zinc uptake assay revealed that SLC39A14 functions as a zinc transporter. Taken together, these results suggest that SLC39A14 plays a role as a zinc transporter during the early stages of adipogenesis.