Open AccessThe prevalence of vitamin D abnormalities in South Asians with type 2 diabetes mellitus in the UK
Author(s) -
Tahrani A. A.,
Ball A.,
Shepherd L.,
Rahim A.,
Jones A. F.,
Bates A.
Publication year - 2010
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/j.1742-1241.2009.02221.x
Subject(s) - medicine , vitamin d and neurology , vitamin d deficiency , type 2 diabetes mellitus , diabetes mellitus , calcifediol , parathyroid hormone , endocrinology , population , type 2 diabetes , cross sectional study , hypovitaminosis , logistic regression , gastroenterology , alkaline phosphatase , calcium , environmental health , pathology , biochemistry , chemistry , enzyme
Summary Background: The high prevalence of both hypovitaminosis D and type 2 diabetes (T2DM) in the Asian community is well recognised, but the impact of diabetes on vitamin D status and vice versa , has not been well reported. Aims: To determine the prevalence of hypovitaminosis D in Asian patients with T2DM and its impact on glycaemic control. Methods: A cross‐sectional study was conducted in a tertiary referral centre in the UK. Two hundred and ten Asian patients aged more than 40 years were included (170 with and 40 without T2DM). Each had a standard bone profile (serum calcium, phosphate and alkaline phosphatase), serum parathyroid hormone and 25‐hydroxycholecalciferol. Results: The prevalence of low serum 25‐hydroxyvitamin D (< 50 nmol/l) was high in the group as a whole (> 80%) and more common in diabetics compared with controls (83% vs. 70%; p = 0.07). This was particularly so in men (82.5% vs. 57.9%; p = 0.02). HbA1c was higher in women with vitamin D deficiency (< 12.5 nmol/l) (8.11 ± 1.11% vs. 7.33 ± 1.32%, p = 0.046). In logistic regression analysis, T2DM was an independent predictor of hypovitaminosis D. In linear regression analysis, vitamin D deficiency was independently related to HbA1c in women with T2DM. Conclusions: Hypovitaminosis D remains a major public health issue in the Asian population and is exaggerated in patients with T2DM. The fact that vitamin D deficient women had higher HbA1c levels raises the possibility that vitamin D replacement may improve glycaemic control.