Open AccessOtosclerosis 1: the aetiopathogenesis of otosclerosis
Author(s) -
Uppal S.,
Bajaj Y.,
Rustom I.,
Coatesworth A. P.
Publication year - 2009
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/j.1742-1241.2009.02045.x
Subject(s) - otosclerosis , medicine , footplate , penetrance , stapes , conductive hearing loss , bone conduction , hearing loss , audiology , surgery , middle ear , genetics , mechanical engineering , biology , engineering , gene , phenotype
Summary Otosclerosis is a bone dystrophy localised to the inner ear and the stapes footplate. Otosclerosis is a frequent cause of deafness in adults. The patient with otosclerosis typically presents with a history of slowly progressive conductive or mixed hearing loss that is usually bilateral and often asymmetric, usually between the ages of 15 and 45 years. The disease is characterised by alternating phases of bone resorption and formation. The majority of studies on families with otosclerosis suggest an autosomal dominant mode of inheritance with incomplete penetrance.